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 citrate de clomiphene prescrit pour les hommes

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MessageSujet: citrate de clomiphene prescrit pour les hommes   Lun 17 Nov 2008, 16:07

http://www.clomiphene.com/research_article/?tx_ttnews%5Bpointer%5D=3&tx_ttnews%5Btt_news%5D=425&tx_ttnews%5BbackPid%5D=77&cHash=c1eae6afe3


Select patients with hypogonadotropic hypogonadism may respond to treatment with clomiphene citrate.


By: Whitten SJ, Nangia AK, Kolettis PN.
Fertil Steril 2006 Sep 26; [Epub ahead of print]


OBJECTIVE: To review the management of male hypogonadotropic hypogonadism (HH) and evaluate the efficacy of clomiphene citrate (CC). DESIGN: Retrospective review. SETTING: Two university-based urology clinics. PATIENT(S): Ten patients referred for male infertility evaluation. INTERVENTION(S): Patients were treated with either clomiphene citrate or injectable gonadotropins. MAIN OUTCOME MEASURE(S): Changes in seminal parameters, gonadotropin levels, serum testosterone, and pregnancy. RESULT(S): Ten men who were evaluated for infertility were diagnosed with HH. Four had Kallmann's syndrome, four idiopathic HH, and two panhypopituitarism. Eight patients were azoospermic, and two were oligospermic on presentation. Three of the four men with adult-onset idiopathic HH responded to CC alone with increases in testosterone, FSH, and LH. Semen parameters in this group also improved, and two of the three men achieved pregnancies with CC alone. Out of the ten men actively attempting conception, four pregnancies were achieved. Three pregnancies (two with CC and one with gonadotropins) were in men diagnosed with adult-onset idiopathic forms of HH. CONCLUSION(S): Select patients with adult-onset idiopathic forms of HH may benefit from a trial of clomiphene citrate.
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MessageSujet: Re: citrate de clomiphene prescrit pour les hommes   Lun 17 Nov 2008, 16:08

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6K-4M0BHNF-8&_user=10&_coverDate=12%2F31%2F2006&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7d9328738e6a840d98aab8687d8e3ea6

Select patients with hypogonadotropic hypogonadism may respond to treatment with clomiphene citrate
Scott J. Whitten M.D.a, , , Ajay K. Nangia M.D.c and Peter N. Kolettis M.D.b

aDivision of Reproductive Endocrinology and Infertility, University of Alabama, Birmingham, Alabama
bDivision of Urology, University of Alabama, Birmingham, Alabama
cDivision of Urology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Received 7 October 2005; revised 9 May 2006; accepted 9 May 2006. Available online 27 September 2006.




Objective
To review the management of male hypogonadotropic hypogonadism (HH) and evaluate the efficacy of clomiphene citrate (CC).
Design
Retrospective review.
Setting
Two university-based urology clinics.
Patient(s)
Ten patients referred for male infertility evaluation.
Intervention(s)
Patients were treated with either clomiphene citrate or injectable gonadotropins.
Main Outcome Measure(s)
Changes in seminal parameters, gonadotropin levels, serum testosterone, and pregnancy.
Result(s)
Ten men who were evaluated for infertility were diagnosed with HH. Four had Kallmann’s syndrome, four idiopathic HH, and two panhypopituitarism. Eight patients were azoospermic, and two were oligospermic on presentation. Three of the four men with adult-onset idiopathic HH responded to CC alone with increases in testosterone, FSH, and LH. Semen parameters in this group also improved, and two of the three men achieved pregnancies with CC alone. Out of the ten men actively attempting conception, four pregnancies were achieved. Three pregnancies (two with CC and one with gonadotropins) were in men diagnosed with adult-onset idiopathic forms of HH.

Conclusion(s)
Select patients with adult-onset idiopathic forms of HH may benefit from a trial of clomiphene citrate.
Key Words: Hypogonadotropic hypogonadism; male infertility; clomiphene citrate
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